Opportunity Information: Apply for RFA PS 21 004
Implementing and Evaluating a Data-to-Care Rx Strategy (RFA PS 21 004) is a CDC cooperative agreement funding opportunity under the U.S. Department of Health and Human Services that focuses on improving HIV treatment outcomes by using near real-time prescription information as a public health action tool. The central idea is to treat delayed or missed antiretroviral (ARV) prescription refills as an early warning signal that someone living with HIV may be slipping off therapy or disengaging from care, then respond quickly with tailored interventions that support adherence and re-engagement. The overall objectives are to increase HIV viral suppression, improve adherence to ARV therapy, and strengthen retention in ongoing HIV care.
The NOFO has three tightly connected purposes. First, recipients are expected to use real-time (or close to real-time) prescription data to identify people with HIV who are late filling ARV prescriptions, and then target those individuals for progressively intensive adherence and retention interventions. That progressive approach implies a stepped response rather than a one-size-fits-all model, typically starting with lower-burden outreach or reminders and escalating to more hands-on navigation, case management, or clinical linkage support if delays continue. Second, the program aims to figure out and document the essential steps and critical elements required to run a Data-to-Care Rx (D2C Rx) strategy effectively, including the practical workflows, partnerships, data handling processes, and decision points that make the approach work in the real world. Third, recipients must develop a D2C Rx implementation protocol along with supporting implementation materials so the strategy can be replicated, scaled, and adopted by other jurisdictions or organizations.
This opportunity is categorized as discretionary funding and uses a cooperative agreement mechanism, which generally means the CDC expects to have substantial involvement during the project period, such as collaborating on strategy development, evaluation design, and dissemination of lessons learned. It sits within the health funding activity category and is associated with CFDA numbers 93.941 and 93.943. The maximum award amount listed is $595,333, and the CDC anticipated making three awards, indicating a small, competitive cohort intended to test and refine the model in a limited number of settings before broader rollout.
Eligibility is broad and includes multiple levels of government (state, county, city or township, and special district governments), independent school districts, public and private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status (excluding higher education institutions in those categories), for-profit organizations other than small businesses, and small businesses. This wide eligibility suggests the CDC was open to a range of entities that can access prescription data through partnerships and can coordinate adherence and retention interventions, including health departments, academic partners, community-based organizations, and private-sector implementers.
Administratively, the opportunity was posted on September 30, 2020, with an application deadline of January 5, 2021, and electronic submissions due by 5:00 p.m. Eastern Time on the closing date. In practical terms, the work supported by this NOFO centers on building or enhancing the capability to ingest and act on prescription fill information quickly, translating that data into prioritized outreach lists, ensuring appropriate privacy and data-sharing arrangements, coordinating with clinical and community partners to contact individuals in a supportive way, and evaluating both outcomes (like viral suppression and retention in care) and implementation factors (like feasibility, timeliness, staffing needs, and the specific workflow steps that are most critical). The end product is not only improved patient outcomes in the funded sites, but also a clearer, standardized playbook for implementing D2C Rx strategies elsewhere.Apply for RFA PS 21 004
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Implementing and Evaluating a Data-to-Care Rx Strategy" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.941, 93.943.
- This funding opportunity was created on Sep 30, 2020.
- Applicants must submit their applications by Jan 05, 2021 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $595,333.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses.
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Frequently Asked Questions (FAQs)
What is the "Implementing and Evaluating a Data-to-Care Rx Strategy" opportunity (RFA PS 21 004)?
This is a CDC cooperative agreement funding opportunity under the U.S. Department of Health and Human Services. It supports projects that improve HIV treatment outcomes by using near real-time prescription information as a public health action tool.
What problem is this funding opportunity trying to address?
The opportunity focuses on improving HIV treatment outcomes by detecting early signs that someone may be falling off antiretroviral therapy (ARV) or disengaging from care. A delayed or missed ARV prescription refill is treated as an early warning signal, prompting timely, tailored support to help people stay on therapy and connected to care.
What are the overall objectives of the program?
The overall objectives are to increase HIV viral suppression, improve adherence to ARV therapy, and strengthen retention in ongoing HIV care.
What does "Data-to-Care Rx (D2C Rx)" mean in this NOFO?
In this context, D2C Rx refers to using real-time (or close to real-time) prescription refill data to identify people with HIV who are late filling ARV prescriptions, then acting on that information through outreach and interventions to support adherence and re-engagement in care.
How is prescription refill data used as a public health action tool?
Recipients are expected to ingest near real-time prescription fill information, identify individuals who are late on ARV refills, and translate those signals into prioritized outreach lists. The goal is to respond quickly and support people before treatment interruptions lead to worse outcomes.
What kinds of interventions are expected once someone is identified as late on an ARV refill?
The NOFO describes a progressively intensive approach to adherence and retention interventions. This implies a stepped response (rather than one-size-fits-all), typically starting with lower-burden outreach or reminders and escalating to more hands-on navigation, case management, or clinical linkage support if refill delays continue.
What does a "progressively intensive" or "stepped" approach mean here?
It means the response escalates based on ongoing need. If initial, lighter-touch outreach is not enough, the program increases intensity over time, potentially adding more direct navigation, case management, and support for linkage back to clinical care.
What are the three main purposes of this NOFO?
The NOFO has three tightly connected purposes: (1) use real-time (or close to real-time) prescription data to identify late ARV refills and target individuals for progressively intensive adherence and retention interventions; (2) determine and document the essential steps and critical elements needed to operate a D2C Rx strategy effectively (including workflows, partnerships, data handling, and decision points); and (3) develop a D2C Rx implementation protocol and supporting materials so the strategy can be replicated and scaled by others.
What deliverables are expected beyond improving outcomes in the funded sites?
Beyond improved patient outcomes (such as viral suppression and retention in care), recipients are expected to produce a clearer, standardized set of materials, including a D2C Rx implementation protocol and supporting implementation materials that enable replication, scaling, and adoption by other jurisdictions or organizations.
What is meant by "implementation protocol" and "supporting implementation materials" in this opportunity?
These are the documented procedures and practical tools that describe how to run the D2C Rx strategy in the real world. The NOFO emphasizes capturing practical workflows, partnerships, data handling processes, and decision points so other jurisdictions or organizations can adopt the approach.
Is this a grant or a cooperative agreement?
This opportunity uses a cooperative agreement mechanism. That generally means CDC expects substantial involvement during the project period, such as collaborating on strategy development, evaluation design, and dissemination of lessons learned.
What does "substantial involvement" by CDC typically imply for awardees?
Based on the NOFO description, it implies CDC collaboration during the project period, including work on strategy development, evaluation design, and sharing or disseminating lessons learned from implementation.
What type of funding is this categorized as?
The opportunity is categorized as discretionary funding and falls within a health funding activity category.
What are the CFDA numbers associated with this opportunity?
The opportunity is associated with CFDA numbers 93.941 and 93.943.
What is the maximum award amount?
The maximum award amount listed is $595,333.
How many awards did CDC anticipate making?
CDC anticipated making three awards.
What does the small number of anticipated awards suggest?
With three anticipated awards, the NOFO suggests a small, competitive cohort intended to test and refine the model in a limited number of settings before broader rollout.
Who is eligible to apply?
Eligibility is broad and includes: state, county, city or township, and special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those categories); for-profit organizations other than small businesses; and small businesses.
What types of organizations are likely to be strong fits based on the program design?
Based on the NOFO description, likely fits include entities that can access prescription data through partnerships and can coordinate adherence and retention interventions, such as health departments, academic partners, community-based organizations, and private-sector implementers.
When was this opportunity posted and when was the application due?
The opportunity was posted on September 30, 2020. The application deadline was January 5, 2021.
What time were electronic submissions due on the closing date?
Electronic submissions were due by 5:00 p.m. Eastern Time on January 5, 2021.
What are the core operational capabilities supported by this NOFO?
The supported work centers on building or enhancing the capability to ingest and act on prescription fill information quickly, translating that data into prioritized outreach lists, establishing appropriate privacy and data-sharing arrangements, coordinating with clinical and community partners for supportive outreach, and evaluating both outcomes and implementation factors.
What kinds of partnerships or coordination does the NOFO emphasize?
The NOFO emphasizes practical workflows and partnerships needed to access and use prescription refill data and to coordinate interventions. It highlights coordination with clinical and community partners to contact individuals in a supportive way.
What does the NOFO indicate about privacy and data sharing?
It notes that recipients should ensure appropriate privacy and data-sharing arrangements as part of building a workflow to ingest and act on prescription fill information quickly.
What outcomes are recipients expected to evaluate?
Recipients are expected to evaluate outcomes such as viral suppression and retention in care.
What implementation factors are recipients expected to evaluate?
The NOFO highlights implementation factors including feasibility, timeliness, staffing needs, and identifying the specific workflow steps that are most critical to making the strategy work.
Why does the NOFO focus on near real-time prescription data instead of delayed reporting?
The program concept relies on speed: delayed or missed ARV refills are treated as early warning signals, and near real-time data enables quicker, more targeted outreach and support before interruptions become prolonged or lead to worse outcomes.
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