Opportunity Information: Apply for RFA HD 25 009
Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research is an NIH grant opportunity (RFA-HD-25-009) that supports exploratory, early-stage studies under the R21 mechanism, with clinical trials not allowed. The focus is on helping the maternal and pediatric HIV research community get more scientific value out of resources that already exist by promoting translation, reuse, and sharing of archived HIV/AIDS datasets and stored specimen collections. Rather than funding new participant recruitment or prospective clinical testing, this NOFO is designed for secondary analyses that can quickly generate fresh insights, new hypotheses, and follow-on research directions that align with the priorities of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), specifically its Maternal and Pediatric Infectious Disease Branch (MPIDB), in coordination with the NIH Office of AIDS Research (OAR).
The core goal is to encourage applicants to take advantage of existing data and specimens and apply modern or advanced analytic approaches to answer high-value questions about HIV/AIDS in maternal, pediatric, and adolescent populations. The scientific scope is broad within that population focus, covering areas such as epidemiology (for example, trends in transmission or outcomes across settings and subgroups), pathogenesis (how disease develops and differs across stages of pregnancy, infancy, childhood, and adolescence), treatment (including patterns of response, resistance, adherence-related signals captured in prior studies, or comparative outcomes across regimens), and the clinical manifestations and complications of HIV/AIDS (including comorbidities and longer-term developmental or health impacts). Because the emphasis is on leveraging archived resources, competitive projects are expected to show a clear plan for using existing datasets and/or specimen repositories to produce new knowledge rather than simply repeating prior published analyses.
Administratively, this is a discretionary grant program run by the National Institutes of Health, categorized under Health, Income Security and Social Services, and associated with CFDA numbers 93.242 and 93.865. The original closing date listed for the opportunity was July 24, 2024, and the maximum award amount (ceiling) is $275,000. As an R21, the program is oriented toward shorter, hypothesis-generating work that can demonstrate feasibility or reveal novel findings that may later justify larger-scale applications.
Eligibility is intentionally expansive to pull in a wide range of institutions and organizations capable of rigorous secondary analysis and data/specimen-driven discovery. Eligible applicants include many types of U.S. governmental entities (state, county, city/township, special district governments, and independent school districts), public and state-controlled and private institutions of higher education, federally recognized Native American tribal governments, tribal organizations that are not federally recognized, public housing authorities/Indian housing authorities, and both nonprofit organizations (with or without 501(c)(3) status) and for-profit organizations (other than small businesses), as well as small businesses and other applicants. The NOFO also highlights additional eligible groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI), along with faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and non-U.S. (foreign) entities. This wide eligibility reflects the intent to broaden participation and accelerate discovery by allowing many sectors to contribute, especially those with access to unique cohorts, archives, repositories, or analytic expertise.
In practical terms, the opportunity is best suited for teams that already have a strong handle on an archived dataset or specimen collection and can clearly explain what new question they will answer, why existing resources are sufficient, and how updated methods (for example, improved statistical modeling, integrative analyses across multiple datasets, or novel laboratory approaches applied to stored specimens) will yield insights relevant to maternal and pediatric HIV. The overall emphasis is on maximizing the scientific return of prior investments in HIV/AIDS research by enabling new analyses that can inform future studies, clinical understanding, and public health strategies for pregnant people, infants, children, and adolescents affected by HIV.Apply for RFA HD 25 009
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.865.
- This funding opportunity was created on 2024-04-24.
- Applicants must submit their applications by 2024-07-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (RFA-HD-25-009)
What is this funding opportunity?
This is an NIH grant opportunity titled "Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research" (RFA-HD-25-009). It supports exploratory, early-stage research projects under the R21 mechanism.
Which NIH institute is involved?
The opportunity aligns with the priorities of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), specifically its Maternal and Pediatric Infectious Disease Branch (MPIDB), in coordination with the NIH Office of AIDS Research (OAR).
What is the main purpose of the program?
The core goal is to increase scientific value from resources that already exist by promoting translation, reuse, and sharing of archived HIV/AIDS datasets and stored specimen collections for maternal, pediatric, and adolescent HIV/AIDS research.
What type of research is the NOFO designed to support?
It is designed for secondary analyses and other work that leverages existing archived datasets and/or stored specimen collections to generate new insights, new hypotheses, and follow-on research directions relevant to maternal and pediatric HIV/AIDS.
Are clinical trials allowed under this opportunity?
No. Clinical trials are not allowed under this R21 funding opportunity.
Does the program support new participant recruitment or prospective clinical testing?
No. The emphasis is on using archived resources rather than funding new participant recruitment or prospective clinical testing.
What populations should the proposed research focus on?
The focus is on maternal, pediatric, and adolescent populations affected by HIV/AIDS, including questions relevant to pregnancy, infancy, childhood, and adolescence.
What scientific topics are within scope?
The scope is broad within the maternal/pediatric/adolescent HIV/AIDS focus. Areas mentioned include epidemiology, pathogenesis, treatment, and clinical manifestations and complications (including comorbidities and longer-term developmental or health impacts).
What are examples of epidemiology questions that could fit?
Examples provided include trends in transmission or outcomes across different settings and subgroups, using existing data sources.
What are examples of pathogenesis questions that could fit?
Examples include studying how HIV disease develops and differs across stages such as pregnancy, infancy, childhood, and adolescence, using archived data and/or stored specimens.
What are examples of treatment-related questions that could fit?
Examples include evaluating patterns of response, resistance, adherence-related signals captured in prior studies, or comparative outcomes across regimens, using existing datasets and/or specimen collections.
What kinds of complications or outcomes are considered relevant?
The opportunity highlights clinical manifestations and complications of HIV/AIDS, including comorbidities and longer-term developmental or health impacts, as being within scope when studied in maternal, pediatric, or adolescent populations using archived resources.
What makes a project competitive given the emphasis on archived resources?
Competitive projects are expected to present a clear plan to use existing datasets and/or specimen repositories to produce new knowledge, rather than simply repeating prior published analyses.
What is the expected analytical approach?
The program encourages the use of modern or advanced analytic approaches to answer high-value questions, such as improved statistical modeling, integrative analyses across multiple datasets, or novel laboratory approaches applied to stored specimens.
What grant mechanism is used and what does that imply?
The opportunity uses the R21 mechanism, which is oriented toward exploratory, early-stage, hypothesis-generating work that can demonstrate feasibility or reveal novel findings that may support later, larger-scale applications.
What is the maximum award amount?
The listed ceiling (maximum award amount) is $275,000.
When was the original closing date listed for this opportunity?
The original closing date listed was July 24, 2024.
What type of program is this administratively?
It is a discretionary grant program run by the National Institutes of Health and is categorized under Health, Income Security and Social Services.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.242 and 93.865.
Who is eligible to apply?
Eligibility is intentionally expansive and includes many types of U.S. governmental entities, higher education institutions (public/state-controlled and private), federally recognized Native American tribal governments, tribal organizations that are not federally recognized, public housing authorities/Indian housing authorities, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and other applicants.
Are specific institution types explicitly encouraged or highlighted as eligible?
Yes. The NOFO highlights eligibility for groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI).
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations are listed among eligible applicants.
Can federal agencies apply?
Yes. Eligible federal agencies are included among the eligible applicant types.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed as eligible.
Are regional organizations eligible?
Yes. Regional organizations are listed among eligible applicants.
Are non-U.S. (foreign) entities eligible to apply?
Yes. Non-U.S. (foreign) entities are included in the eligible applicant types.
What kinds of teams are best suited for this opportunity?
Teams that already have a strong handle on an archived dataset or specimen collection and can clearly explain (1) what new question they will answer, (2) why existing resources are sufficient, and (3) how updated methods will yield insights relevant to maternal and pediatric HIV/AIDS.
What is the broader rationale for this funding opportunity?
The overall emphasis is on maximizing the scientific return of prior investments in HIV/AIDS research by enabling new analyses of existing data and specimens to inform future studies, clinical understanding, and public health strategies for pregnant people, infants, children, and adolescents affected by HIV.
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