Opportunity Information: Apply for CDC RFA PS18 1812
The Sustainable Healthcenter Implementation Pre-Exposure Prophylaxis (PrEP) Pilot (SHIPP) is a CDC-funded cooperative agreement announced by the Department of Health and Human Services, Centers for Disease Control and Prevention (NCHHSTP), under funding opportunity number CDC RFA PS18-1812 (CFDA 93.939). It was released on March 29, 2018, with applications due by April 9, 2018 at 11:59 p.m. ET. The program is a discretionary grant structured as a cooperative agreement, which typically means the CDC expects to be substantially involved in the planning, implementation, and oversight of the project rather than simply issuing funds and receiving periodic reports.
The opportunity is designed to support one award to a single community-based organization (CBO) that can lead an observational cohort demonstration project focused on PrEP delivery in community health center settings. The award ceiling is $833,025, and the CDC anticipated making exactly one award. While the eligibility category is listed broadly as "Others (see text)," the narrative makes clear that the intended applicant is a CBO with the operational capacity to work directly with clinical partners, including the ability to contract with clinics and coordinate multi-site activities.
The central purpose of SHIPP is to generate real-world evidence about who uses PrEP, how they use it over time, and what outcomes result when PrEP is delivered through community health centers. The project aims to assess the socioeconomic, demographic, and behavioral characteristics associated with HIV acquisition risk among people who start PrEP, remain on PrEP, or stop taking PrEP. In other words, it is not just measuring uptake; it is trying to understand patterns of initiation, persistence, and discontinuation, and how those patterns relate to risk factors and lived circumstances that can influence prevention outcomes.
A major emphasis is also placed on the financial and operational side of PrEP delivery. The project is expected to document the costs associated with PrEP medications and the clinical services tied to PrEP care, along with how clinics are reimbursed for those medications and services. This component is meant to clarify what it takes for community health centers to sustain PrEP programs in routine practice, including where financial barriers or reimbursement gaps may exist.
Operationally, the funded CBO must be able to partner with clinics that will help coordinate systematic assessments while patients are prescribed PrEP, including clinical and behavioral safety monitoring. The project must evaluate medication adherence levels among people prescribed PrEP and identify determinants of adherence, recognizing that adherence is shaped by many factors such as access challenges, side effects, stigma, competing life needs, and the quality of support provided by the clinic. The announcement also explicitly anticipates that some participants may receive only basic adherence support while others may receive supplementary adherence interventions, and the project should be able to compare adherence patterns across these different levels of support to understand what helps people stay on PrEP effectively.
Another key requirement is to evaluate how clinicians follow the U.S. Public Health Service (PHS) PrEP guidelines in actual practice. The project is expected to measure clinician compliance and variation relative to guideline recommendations, then examine how those differences relate to patient outcomes. This reflects a practical concern: even when guidelines exist, clinics may implement them with varying levels of fidelity due to staffing, training, patient volume, laboratory access, documentation systems, or local workflows. SHIPP is structured to capture and analyze those real-world variations rather than assuming uniform implementation.
To accomplish these goals, the project will collect detailed information on PrEP services delivered in community health centers and link that service-delivery information to patient outcomes and patient behaviors. The intent is to create a clear picture of how guideline-recommended clinical services and patient behavior interact in routine care settings, and to determine what happens when services align closely with guidelines versus when they deviate. Finally, the opportunity notes that standard HIV prevention performance measures aligned with accountability expectations are included in the notice of funding opportunity, signaling that the project will be expected to track and report consistent prevention program indicators in addition to its observational cohort analyses.Apply for CDC RFA PS18 1812
- The Department of Health and Human Services, Centers for Disease Control - NCHHSTP in the health sector is offering a public funding opportunity titled "Sustainable Healthcenter Implementation Pre-Exposure Prophylaxis (PrEP) Pilot (SHIPP)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.939.
- This funding opportunity was created on Mar 29, 2018.
- Applicants must submit their applications by Apr 09, 2018 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $833,025.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is the SHIPP PrEP Pilot opportunity?
The Sustainable Healthcenter Implementation Pre-Exposure Prophylaxis (PrEP) Pilot (SHIPP) is a CDC-funded cooperative agreement to support an observational cohort demonstration project focused on PrEP delivery in community health center settings.
Which agency is funding SHIPP?
SHIPP is funded by the U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), specifically within NCHHSTP.
What is the funding opportunity number and CFDA number?
The funding opportunity number is CDC RFA PS18-1812, and the CFDA number is 93.939.
What type of grant is SHIPP?
SHIPP is a discretionary grant structured as a cooperative agreement. This structure typically means CDC expects to be substantially involved in planning, implementation, and oversight, rather than only providing funds and receiving periodic reports.
When was the opportunity released and when were applications due?
The opportunity was released on March 29, 2018. Applications were due April 9, 2018 at 11:59 p.m. ET.
How many awards did CDC anticipate making?
CDC anticipated making exactly one award.
What is the maximum award amount (award ceiling)?
The award ceiling is $833,025.
Who is the intended applicant for this opportunity?
Although eligibility is listed broadly as "Others (see text)," the description indicates the intended applicant is a single community-based organization (CBO) with the operational capacity to lead the project and work directly with clinical partners.
Can more than one organization apply together?
The opportunity is designed to support one award to a single CBO that can lead the project. The funded organization is expected to work through partnerships (including contracting with clinics), but the award itself is intended for one lead organization.
What kinds of partners are expected in SHIPP?
The funded CBO is expected to partner with community health centers and other clinical partners, including the ability to contract with clinics and coordinate multi-site activities.
What is the overall purpose of the SHIPP project?
The purpose is to generate real-world evidence about who uses PrEP, how PrEP is used over time, and what outcomes occur when PrEP is delivered through community health centers.
Is SHIPP mainly about increasing PrEP uptake?
No. While PrEP use is central, SHIPP is described as going beyond uptake by examining patterns of PrEP initiation, persistence, and discontinuation, and how those patterns relate to HIV risk factors and lived circumstances.
What population or participant group is SHIPP trying to understand?
SHIPP focuses on people who start PrEP in community health center settings and examines differences among those who remain on PrEP over time versus those who stop taking it, in relation to HIV acquisition risk factors and related characteristics.
What characteristics does the project aim to assess?
The project aims to assess socioeconomic, demographic, and behavioral characteristics associated with HIV acquisition risk among people who start PrEP, continue PrEP, or discontinue PrEP.
What is meant by an "observational cohort demonstration project" in SHIPP?
Based on the description, SHIPP is intended to observe and track a cohort of people receiving PrEP in real-world community health center care, linking services delivered to patient behaviors and outcomes, rather than assuming uniform implementation across sites.
Does SHIPP include adherence monitoring?
Yes. The project must evaluate medication adherence levels among people prescribed PrEP and identify determinants of adherence.
What factors does SHIPP recognize as influencing PrEP adherence?
The description notes that adherence can be shaped by factors such as access challenges, side effects, stigma, competing life needs, and the quality of support provided by the clinic.
Does SHIPP require comparing different levels of adherence support?
Yes. The announcement anticipates that some participants may receive only basic adherence support while others receive supplementary adherence interventions, and the project should be able to compare adherence patterns across these different support levels.
What clinical monitoring is expected as part of the project?
The project is expected to coordinate systematic assessments while patients are prescribed PrEP, including clinical and behavioral safety monitoring.
Does SHIPP evaluate how clinicians follow PrEP guidelines?
Yes. A key requirement is to evaluate how clinicians follow the U.S. Public Health Service (PHS) PrEP guidelines in actual practice.
What does SHIPP mean by measuring clinician "compliance and variation" with guidelines?
The project is expected to measure clinician compliance and variation relative to guideline recommendations, then examine how differences in implementation relate to patient outcomes.
Why does SHIPP focus on variation in guideline implementation?
The description emphasizes practical, real-world reasons clinics may differ in guideline fidelity, including staffing, training, patient volume, laboratory access, documentation systems, and local workflows.
What data linkages are expected in SHIPP?
The project will collect detailed information on PrEP services delivered in community health centers and link that service-delivery information to patient outcomes and patient behaviors.
What outcomes is SHIPP trying to connect to PrEP service delivery?
The project aims to understand what happens when guideline-recommended clinical services and patient behavior interact in routine care settings, including outcomes when services align closely with guidelines versus when they deviate.
Does SHIPP include a financial analysis component?
Yes. A major emphasis is placed on documenting the costs associated with PrEP medications and the clinical services tied to PrEP care.
What specific cost and reimbursement information is SHIPP expected to document?
The project is expected to document costs for PrEP medications and related clinical services, as well as how clinics are reimbursed for those medications and services.
Why is the program focusing on costs and reimbursement?
This component is intended to clarify what it takes for community health centers to sustain PrEP programs in routine practice and to identify where financial barriers or reimbursement gaps may exist.
Are there required performance measures for SHIPP?
Yes. The opportunity notes that standard HIV prevention performance measures aligned with accountability expectations are included in the notice of funding opportunity, indicating the project will be expected to track and report consistent prevention program indicators in addition to observational cohort analyses.
What does the cooperative agreement structure mean for the awardee's relationship with CDC?
Because this is a cooperative agreement, CDC is expected to be substantially involved in planning, implementation, and oversight of the project, rather than acting only as a funder receiving periodic reports.
What operational capabilities does the lead CBO need?
The narrative indicates the lead CBO should have the operational capacity to work directly with clinical partners, including contracting with clinics and coordinating multi-site activities, while supporting systematic assessments, monitoring, and data collection tied to PrEP delivery and outcomes.
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